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. 2006 Sep 26;103(40):14901–14906. doi: 10.1073/pnas.0604979103

Fig. 5.

Fig. 5.

Administration of Dp44mT and Triapine to mice up-regulates the growth and metastasis suppressor Ndrg-1 in tumor xenografts but not the liver. Expression of the Fe-regulated genes Ndrg1, TfR1, and VEGF1 is down-regulated in liver (A) and up-regulated in tumor (B) after treatment of nude mice bearing DMS-53 xenografts with Dp44mT (0.75 mg/kg per day) or Triapine (12 mg/kg per day) once per day, 5 days/week for 2 weeks. The densitometric results are mean ± SD from three experiments. *, P < 0.05; **, P < 0.01; ***, P < 0.001.