Table 1.
Effector* | Sakai ID | Family† | Context‡ | Evidence§ |
---|---|---|---|---|
EspX1 | ECs0025 | PPR | O-I 1 | H |
EspY1 | ECs0061 | SopD-N | C-I | B |
EspY2 | ECs0073 | SopD-N | O-I 3 | H |
EspY3 | ECs0472 | SopD-N; PRR | C-I | H |
NleB2-1 | ECs0846 | NleB | Sp3 | H |
NleC | ECs0847 | NleC | Sp3 | B |
NleH1-1 | ECs0848 | NleH | Sp3 | SC |
NleD | ECs0850 | NleD | Sp3 | B |
EspX2 | ECs0876 | PPR | O-I 37 | B |
EspF2-1′ | ECs1126 | EspF | Sp4 | H ψ |
EspV′ | ECs1127 | AvrA | Sp4 | Neg ψ |
EspX7 | ECs1560¶ | PPR; LRR | Sp6 | S |
EspN | ECs1561¶ | CNF | Sp6 | S |
NleB2-2′ | ECs1566 | NleB | Sp6 | H ψ |
EspO1-1 | ECs1567 | OspE | Sp6 | SCFB |
EspK | ECs1568 | LRR | Sp6 | SFB |
NleG2-1′ | ECs1810/1 | NleG | Sp9 | S ψ |
NleA | ECs1812 | NleA | Sp9 | S |
NleH1-2 | ECs1814 | NleH | Sp9 | SCFB |
NleF | ECs1815 | NleF | Sp9 | SB |
EspO1-2 | ECs1821 | OspE | Sp9 | H |
NleG | ECs1824 | NleG | Sp9 | SF |
EspM1 | ECs1825 | IpgB | Sp9 | SF |
NleG9′ | ECs1828 | NleG | Sp9 | H ψ |
NleG2-2 | ECs1994‖ | NleG | Sp10 | SCF |
NleG6-1 | ECs1995‖ | NleG | Sp10 | SCF |
NleG5-1 | ECs1996‖ | NleG | Sp10 | SCF |
EspR1 | ECs2073 | LRR | O-I 62 | H |
EspR2′ | ECs2074/5 | LRR | O-I 62 | H ψ |
NleG5-2 | ECs2154‖ | NleG | Sp11 | S |
NleG6-2 | ECs2155‖ | NleG | Sp11 | S |
NleG2-3 | ECs2156‖ | NleG | Sp11 | S |
NleG7′ | ECs2226** | NleG | Sp12 | B ψ |
NleG3′ | ECs2227/8†† | NleG | Sp12 | H ψ |
NleG2-4′ | ECs2229 | NleG | Sp12 | H ψ |
EspL1 | ECs2427 | AR | C-I | H |
EspR3 | ECs2672 | LRR | C-I | H |
EspR4 | ECs2674 | LRR | C-I | H |
EspJ | ECs2714 | EspJ | Sp14 | SC |
TccP | ECs2715 | EspF | Sp14 | S |
EspM2 | ECs3485 | IpgB | Sp17 | SF |
NleG8-2 | ECs3486 | NleG | Sp17 | SCF |
EspW | ECs3487 | HopW | Sp17 | SC |
NleG6-3′ | ECs3488†† | NleG | Sp17 | B ψ |
EspL2 | ECs3855 | AR | SpLE3 | SF |
NleB1 | ECs3857 | NleB | SpLE3 | SCF |
NleE | ECs3858 | NleE | SpLE3 | SF |
EspF1 | ECs4550 | EspF | LEE | S |
EspB | ECs4554 | EspB | LEE | S |
Tir | ECs4561 | Tir | LEE | B |
Map | ECs4562 | IpgB | LEE | S |
EspH | ECs4564 | EspH | LEE | SB |
EspZ | ECs4571 | EspZ | LEE | SFB |
EspG | ECs4590 | EspG | LEE | SB |
EspL3′ | ECs4642/3†† | AR | O-I 152 | H ψ |
EspY4 | ECs4653 | SopD-N | O-I 153 | B |
EspX3′ | ECs4654/5 | PPR | O-I 153 | H ψ |
EspY5′ | ECs4657 | SopD-N | O-I 153 | H ψ |
EspL4 | ECs4935 | AR | C-I | H |
EspX4 | ECs5021 | PPR | C-I | Neg |
EspX5 | ECs5048 | PPR | C-I | H |
EspX6 | ECs5295 | PPR | O-I 174 | H |
*Named according to a scheme based on the P. syringae scalable nomenclature for Hrp-dependent effectors (see Materials and Methods). TccP is also known as EspFu or EspF2-2 (this study).
†LRR, leucine-rich repeats; AR, ankyrin repeats; PPR, pentapeptide repeats; SopD-N, SopD N-terminal domain.
‡Prophage nomenclature as in Hayashi et al. (15); O-I, O-island, nomenclature as in Perna et al. (56); C-I, “coli island,” refers to gene clusters present in some or all E. coli genomes but absent in related species such as S. enterica.
§Confirmatory evidence. S, detected in secretome of ΔsepL mutant; C, translocation detected by using CyaA fusion; F, translocation detected using FLAG tag; B, translocation detected by using β-lactamase fusion; H, homologous to known effector but not confirmed by translocation assay; Neg, negative using β-lactamase fusion; ψ, predicted pseudogene.
¶Frame-shift present in EHEC O157:H7 EDL933.
‖Near identical copies in genome (>95% identity): ECs1994/ECs2156; ECs1995/ECs2155; ECs1996/ECs2154.
**Miscalled start codon. CDS length should be 651 nt.
††Not annotated as pseudogene in EHEC O157:H7 Sakai (15).