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Working model of the dsdCXA locus and d-serine metabolism. Both DsdX and CycA are predicted to lie in the inner membrane (5), and our observations are in agreement with this prediction. cycA transcription is controlled by σ54 and Nac (27, 40). Once d-serine enters the cell, it interacts with DsdC, which then induces dsdXA expression. d-Serine is degraded to pyruvate and ammonia by DsdA.
