TABLE 2.
Classification of potential virulence genes identified in OSU18a
| Virulence factor classification | No. of intact genes in F. tularensis
|
No. of pseudogenes in F. tularensis
|
Total | |||
|---|---|---|---|---|---|---|
| OSU18 and Schu4 | OSU18, but no corresponding CDS in Schu4 | OSU18 and Schu4 | OSU18 but intact in Schu4 | Schu4 but intact in OSU18 | ||
| Stress response, efflux pumps, and antibiotic resistance | 49 | 1 | 3 | 5 | 3 | 61 |
| Lipopolysaccharide, capsule, and polysaccharide decoration | 50 | 0 | 0 | 0 | 0 | 50 |
| Posttranslational processing and secretion | 34 | 0 | 4 | 2 | 0 | 40 |
| F. tularensis pathogenicity island | 30 | 0 | 0 | 4 | 0 | 34 |
| Intracellular survival | 19 | 0 | 2 | 2 | 1 | 24 |
| Iron acquisition, transport, and metabolism | 19 | 0 | 1 | 0 | 1 | 21 |
| Pili and outer membrane proteins | 14 | 0 | 0 | 3 | 0 | 17 |
| Transcriptional and translational regulation | 11 | 0 | 0 | 2 | 0 | 13 |
| Extracellular toxins, enzymes, and effectors | 5 | 0 | 0 | 2 | 1 | 8 |
| Total | 231 | 1 | 10 | 20 | 6 | 268 |
a
The numbers of genes found intact and as pseudogenes in each strain are indicated. A list of virulence genes can be found in Table S4 in the supplemental material.