TABLE 5.
S. aureus SOS response-induced transcripts
| Category and qualifiera | Fold inductionb | Common name | Locusc | Description |
|---|---|---|---|---|
| DNA metabolism | ||||
| sa_c10340s10724_s_at | 4.9* | sbcC | SA1382 | Exonuclease SbcC |
| sa_c1727s1464_a_at | 4.3 | sbcD | SA1381 | Exonuclease SbcD |
| sa_c4052s9933_a_at | 44.5 | ssb | N315-SA1792 | Single-stranded DNA-binding protein |
| sa_c8354s7326_a_at | 2.4 | uvrA | SA0824 | Excinuclease ABC, A subunit |
| sa_c10546s11006_s_at | 4.1 | uvrB | SA0823 | Excinuclease ABC, B subunit |
| sa_c10309s10698_a_at | 14.5* | N315-SA1196 | ImpB/MucB/SamB family protein | |
| sa_i875ur_x_at | 36.2* | SA1400 | ImpB/MucB/SamB family protein | |
| Hypothetical | ||||
| sa_c2404s9766cs_s_at | 46.8 | MSSA476-SAS064 | Conserved hypothetical protein | |
| sa_c4550s9974_at | 2.2 | MSSA476-SAS070 | Conserved hypothetical protein | |
| sa_c4556s9980_x_at | 2.1 | MSSA476-SAS072 | Conserved hypothetical protein | |
| sa_c4049s9931_a_at | 42.1* | MSSA476-SAS1903 | Putative phage regulatory protein | |
| sa_c4031s9915_at | 8.0* | Mu50-SAV0881 | Conserved hypothetical protein | |
| sa_c10677s11128_at | 2.3 | Mu50-SAV2001 | Putative lipoprotein | |
| sa_c4046s9927_at | 17.4* | MW2-MW1918 | Conserved hypothetical protein | |
| sa_c4075s9947_at | 86.9* | MW2-MW1930 | Conserved hypothetical protein | |
| sa_c8469s7429_a_at | 2.2 | N315-SA0751 | Conserved hypothetical protein | |
| sa_c4058s9936_a_at | 40.9 | N315-SA1795 | Conserved hypothetical protein | |
| sa_c4070s9942_a_at | 83.0 | N315-SA1799 | Conserved hypothetical protein | |
| sa_c10141s10553_s_at | 35.1 | N315-SA1803 | Conserved hypothetical protein | |
| sa_c7177s10148_a_at | 7.6* | N315-SA1821 | Conserved hypothetical protein | |
| sa_c6248s5424_a_at | 2.7* | N315-SA2352 | Conserved hypothetical protein | |
| sa_c7132s6241_a_at | 15.5* | SA0436 | Conserved hypothetical protein | |
| sa_c1071s9138_a_at | 2.0 | SA1189 | Acetyltransferase | |
| sa_c1705s1441_a_at | 30.8 | SA1375 | Conserved hypothetical protein | |
| sa_c1960s1685_a_at | 2.8 | SA1438 | Conserved hypothetical protein | |
| sa_c3900s3368_at | 33.3 | SA1986 | Conserved hypothetical protein | |
| sa_c3910s3377_a_at | 8.0 | SA1988 | Conserved hypothetical protein | |
| sa_c10125s8848_a_at | 20.6 | SA1999 | Conserved hypothetical protein | |
| sa_c4628s3951_a_at | 6.1 | SA2162 | Conserved hypothetical protein | |
| Miscellaneous | ||||
| sa_c8264s7244_at | 2.3 | nrdI | SA0791 | NrdI protein |
| sa_c1810s1538_a_at | 6.9* | tyrA | SA1401 | Prephenate dehydrogenase |
| sa_c6244s5421_a_at | 2.1 | SA2579 | Phytoene dehydrogenase | |
| Prophage | ||||
| sa_c10417s10840_s_at | 32.2 | dut | SA0357 | Deoxyuridine 5-triphosphate nucleotidohydrolase |
| sa_c9918s10462_a_at | 3.2 | int | N315-SA1810 | Integrase |
| sa_c10465s10903_s_at | 33.5 | BA000017///BA000018 | Phage antirepressor protein | |
| sa_c10466s10905_a_at | 42.5 | BA000017///BA000018 | Phage antirepressor protein | |
| sa_c4046s9927_a_at | 67.8* | BA000017///BA000018 | Endodeoxyribonuclease RusA | |
| sa_i10903u_x_at | 34.9 | BA000017///BA000018 | Phage antirepressor protein | |
| sa_c4040s9922cs_s_at | 26.2 | BA000017///BA000018 | Conserved hypothetical protein | |
| sa_c10668s11120_a_at | 7.4 | MRSA252-SAR2051 | Hypothetical protein | |
| sa_c2375s1984_a_at | 2.7* | Mu50-SAV0874 | phi PVL ORF 51 homolog | |
| sa_c3991s9882_a_at | 4.3 | Mu50-SAV1954 | phi PVL ORF 18-19-like protein | |
| sa_c3992s9884_a_at | 5.8 | Mu50-SAV1955 | phi PVL ORF 15 and 16 homolog | |
| sa_c4039s9920_at | 6.9* | Mu50-SAV1979 | phi PVL ORF 50 homolog | |
| sa_c3994s9885_s_at | 4.6 | MW2-MW1895 | Conserved hypothetical protein | |
| sa_c4057s9934_a_at | 38.7 | MW2-MW1923 | Conserved hypothetical protein | |
| sa_c3995s9886_a_at | 6.8 | N315-SA1767 | Conserved hypothetical protein | |
| sa_c4005s9893_a_at | 4.0 | N315-SA1769 | Conserved hypothetical protein | |
| sa_c4009s9897_a_at | 4.0 | N315-SA1770 | Conserved hypothetical protein | |
| sa_c4010s9899_at | 4.9 | N315-SA1771 | Conserved hypothetical protein | |
| sa_c4014s9903_a_at | 4.2 | N315-SA1773 | Conserved hypothetical protein | |
| sa_c10670s11122_a_at | 5.2 | N315-SA1774 | Conserved hypothetical protein | |
| sa_c10672s11124_a_at | 6.0 | N315-SA1775 | Conserved putative Clp protease | |
| sa_c4020s9905_at | 11.5 | N315-SA1776 | Conserved hypothetical protein | |
| sa_c10134s10547_a_at | 15.6 | N315-SA1777 | Conserved hypothetical protein | |
| sa_c4022s9907_a_at | 23.9 | N315-SA1778 | Conserved hypothetical protein | |
| sa_c4024s9909_a_at | 42.7 | N315-SA1779 | Conserved hypothetical protein | |
| sa_c4026s9911_at | 41.9 | N315-SA1780 | Conserved hypothetical protein | |
| sa_c4048s9929_a_at | 43.3 | N315-SA1790 | Conserved hypothetical protein | |
| sa_c9913s10456_a_at | 75.3* | N315-SA1793 | Conserved hypothetical protein | |
| sa_c4060s9937_a_at | 41.0* | N315-SA1797 | Conserved hypothetical protein | |
| sa_c7182s10152cs_s_at | 8.6 | SA2014 | Phage terminase family protein | |
| Protein metabolism | ||||
| sa_c1812s1540_a_at | 9.0 | SA1402 | Putative glutamyl aminopeptidase | |
| Regulation | ||||
| sa_c9575s8335_a_at | 4.6 | lexA | SA1374 | LexA repressor |
| sa_c10143s10555cv_s_at | 28.4 | N315-SA1804 | Putative transcriptional regulator | |
| sa_c1737s1469_a_at | 4.8* | mscL | N315-SA1182 | Large-conductance mechanosensitive channel |
| Virulence | ||||
| sa_c4094s3450_a_at | 3.4 | hlb | SA2003 | Phospholipase C |
| sa_c10522s10973_s_at | 2.3 | srtA | SA2539 | Sortase |
| sa_c7169s10140_a_at | 24.9 | SA0901 | Pathogenicity island protein | |
| sa_c10151s10571_a_at | 9.9 | SA0902 | Pathogenicity island protein | |
| sa_c10150s10567_a_at | 7.4 | SA0903 | Pathogenicity island protein | |
| sa_c7173s10144_at | 8.1 | SA0904 | Pathogenicity island protein |
a
Affymetrix S. aureus GeneChip descriptive representing indicated predicted ORF.
b
*, transcript was below the lower limits of sensitivity in unstressed cells, and thus the amount of change represents an estimate.
c
S. aureus strain COL locus, unless otherwise indicated (strain preceeds locus identifier).