Figure 2.

Interleukin-4 (IL-4) inhibition of IL-1-induced expression of MMP-3 mRNA is dose dependent. Total RNA was isolated from HGF cultures 6 hours after addition of 100 ng/ml IL-1β alone or together with the indicated doses of IL-4. Shown are data from three independent experiments, each of which utilized RNA isolated from three pooled HGF cultures established from three different donors. (* p < 0.05; ** p<0.01 vs. IL-1 alone)