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c-Src and PDGFR are connected functionally to each other and provide links to cell-cycle regulators in Gq-coupled 5-HT2B receptor mitogenic signaling. c-Src either acts alone to control cyclin E induction or in concert with a RTK PDGFR to induce cyclin D1 expression via the ERK/MAPK pathway. This action raises the level of pRb phosphorylation and triggers cell-cycle progression.
