Figure 3.

(A) Truncating frameshift mutation in the coding (A)₈ repeat of exon 8 of the RIZ gene. MSI(+) tumor sample H2AT (Lower) has a 1-bp deletion in this repeat. (B) Examples of truncating frameshift mutations in the coding (A)₉ repeat of exon 8 of the RIZ gene. MSI(+) tumor sample 5381T (Center) has a 1-bp deletion in this repeat. MSI(+) tumor sample 8201T (Lower) has a 2-bp deletion in this repeat. (C) Colon cancer cell line HCT116 is homozygous/hemizygous for a 1-bp deletion in the (A)₉ repeat of exon 8 of RIZ, and endometrial cell line AN3CA has both 1- and 2-bp deletions in this repeat. MSI(+) colon cell lines LoVo, LS411N, and LS174T also have 1-bp deletions in this repeat, as does the ovarian cell line MDAH2774.