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Phenotype profiles of APC isolated from MOPC315 tumors. (A) APC I cells were triple-stained, and gated class II+ CD11b+ cells were analyzed for CD11c, CD40, or CD86 expression, compared with isotype-matched control Abs (dashed lines). (B) MOPC315 tumors of various sizes were double-stained, and frequencies of class II+ CD11b+ and class II+ CD11b− populations were plotted as a function of serum M315 concentration [categorical (nonlinear) abscissa].
