Figure 4.

Survival profiles for γHV-68-infected I-A^b−/− mice boosted with recombinant vaccinia viruses. The I-A^b−/− mice were infected i.n. with γHV-68 and boosted with the recombinant vaccinia viruses, as described in the Fig. 1 legend. The survival profiles were then determined for groups of 20 mice, with any animals that were severely affected being terminated. Vaccinia virus infection alone did not cause any mortality in I-A^b−/− mice, and the pattern of illness in the vacc-LCMV^b group was indistinguishable from that for other controls given γHV-68 alone (data not shown). The mice given vacc-p56 lived significantly longer (P = 0.0003 by logrank test) than those injected with vacc-p79 or vacc-LCMV^b.