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. 2006 Oct 13;2(10):e135. doi: 10.1371/journal.pcbi.0020135

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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T_sat represents the concentration that T cells approach as the duration of ART increases. The solid line shows how the critical efficacy depends on T_sat. The dotted line indicates a typical drug efficacy estimated for standard combination ART (ɛ ≈ 0.7), and the dashdot line indicates the critical efficacy when T_sat = T ₀ = 595 cells/μl, i.e., ɛ_c = 0.1402.