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. 2000 Feb 29;97(6):2731–2736. doi: 10.1073/pnas.050588297

Figure 1.

Figure 1

In vitro natural killing is defective in a Ly49A Tg mouse strain. (A) Spleen cells from WT and Ly49A Tg mice were stained with anti-Ly49A, anti-NK1.1, and anti-CD3. Profiles for Ly49A expression on cells gated on CD3− or CD3+ populations are shown. The numbers represent the percentage of cells within the quadrant among all viable cells. (B) Splenocytes from WT (□) and Ly49A Tg (○) mice were used in 4-hr 51Cr-release cytotoxicity assays against YAC-1, RMA-S, and B16 targets at varying effector/target (E:T) ratios as indicated. Results are expressed as the mean percentage specific lysis ± SD of triplicate wells.