Fig. 1.

Overview of the LSD1 structure. (A) Domain organization of LSD1. The SWIRM domain is shown in green, the AOL domain is in blue (the FAD-binding subdomain) and cyan (the substrate-binding subdomain), and the Tower domain is in yellow. The N-terminal flexible region and the C-terminal tail that are not included in the structure determination are colored in gray. (B) Ribbon diagram of the LSD1 structure. The molecule is colored as in A. FAD is in ball-and-stick representation and is colored in red. (C) Structural-based sequence alignments of the SWIRM and AOL domains of LSD1 and its homologs. Secondary structure assignments from the LSD1 crystal structure are shown as cylinders (α-helices) and arrows (β-strands) above the aligned sequences and colored as in B.