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BCR crosslinking increases Btk protein dosage in murine splenic B lymphocytes. Wild-type (Upper) or xid (Lower) splenic B lymphocytes were stimulated by cross-linking BCR with anti-IgM (20 μg/ml) for increasing periods of time (0, 4, 8 hours) as indicated. Cells were fixed and immunostained with a nonspecific antibody (open histograms), anti-Btk (filled histograms), or anti-CD80 (gray histograms) followed by the appropriate fluorescent-tagged secondary antibody.
