Fig. 1.

Summary of results for the whole-genome admixture scan and characteristics of the 8q24 peak of association. (a) We present the LOD score at equally spaced points across the genome. The chromosome 8 peak is marked by a rise to 7.14. (b) We can use the data to calculate a probability distribution for the position of the peak. It aligns with the microsatellite and SNP recently associated with prostate cancer by Amundadottir et al. (13) (dashed line). (c) The 95% credible interval spans 3.8 Mb (125.68–129.48 Mb in build 35 of the human reference sequence) and contains nine known genes, including the c-MYC oncogene (diagram taken from http://genome.ucsc.edu) (data from the May 2004 genome assembly).