Fig. 2.

To formally test for a relationship between age of onset and contribution to the chromosome 8 locus, we rank-ordered the individuals by age of onset and then calculated a score for increasing age cutoffs. The score rises to 5.40 above the expectation for 1,176 individuals diagnosed at <72 years of age. To evaluate whether this rise is unexpected, we permuted the data 1,000,000 times, randomizing scores with respect to individuals' ages of onset (guaranteeing that there is no relationship between age of diagnosis and contribution to the evidence of association). In only 318 of 1,000,000 permutations did we see a rise as high as in our data (P < 0.00032).