Table 2.
Admixture scan summaries
| No. of cases | No. of controls | Peak LOD score | |
|---|---|---|---|
| All prostate cancer cases | 1,597 | 873 | 4.07 |
| High grade (Gleason score >7) | 316 | 873 | 2.68 |
| Advanced stage (regional or metastatic cancer) | 414 | 873 | 2.81 |
| Family history (prostate cancer in a first-degree relative) | 281 | 873 | 1.86 |
| Age of diagnosis of <72 years and high-density genotyping at 8q24 | 1,176 | 873 | 8.39* |
| Drop out every even marker from run no. 5 to demonstrate independence of markers used | 1,176 | 873 | 8.95* |
| Drop out every odd marker from run no. 5 to demonstrate independence of markers used | 1,176 | 873 | 6.65* |
| Diagnosis at <72 years of age, high density and best model of 1.54-increased risk because of African ancestry | 1,176 | 873 | 9.39* |
| Integrating over age-of-diagnosis cutoffs as a formal test for statistical significance | 1,597 | 873 | 7.14* |
*Indicates a scan that meets formal criteria for genome-wide statistical significance.