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Titration of agonist activity of purified Fab 59 using the luciferase reporter assay (described in Materials and Methods). Fab 59 contained two cMpl-R-binding peptides, HC CDR3 clone X4c and LC CDR2 clone LR2–19. NIH 3T3 cells were transfected with cMpl-R and the Fos promoter/luciferase reporter construct. Fab59 (diamond) and rhTPO (square) were titrated for activity testing.
