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. 2006 Sep 15;103(39):14465–14470. doi: 10.1073/pnas.0606450103

Fig. 2.

Fig. 2.

Histology of the loCII-D1CC mouse. (A–C) Histology of joints from the loCII-D1CC mouse. Although no changes are observed 1 week after the boost (A), pannus formation over articular cartilage and proliferating synoviocytes (p and s, respectively; B), and thinning of articular cartilage (c; C) are observed at 8 and 15 weeks after the boost, respectively. Bone (b) also is labeled. (D–F) Histology of joints in the loCII-DBA/1 mouse shows no changes at 1 (D), 8 (E), and 15 (F) weeks after the boost. (G and H) Nodules are observed in the loCII-D1CC mouse. Three weeks after the boost, granulomas (g; G) and nodules (h; H) are observed only in the loCII-D1CC mouse.