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Interstitial pneumonitis is observed only in loCII-D1CC mice. Histology of lungs 6 months after the boost in loCII-D1CC and loCII-DBA/1 mice. Fibrosis, infiltrating mononuclear cells (f and im, arrow, respectively; A), and newly produced elastic fiber (e, arrow; B) are observed in lungs of the loCII-D1CC mouse but not in those of the loCII-DBA/1 mouse (C and D). A and C were stained with HE. B and D were stained with elastica and kernechtrot stains to visualize elastic fibers.
