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Fore limbs of the loCII-D1CC mouse reveal extensive joint destruction. Fifteen months after the boost, fore limbs of loCII-D1CC (A) and loCII-DBA/1 (B) mice were stained with Alizarin and Alcian blue, which stain bone red and cartilage blue. Note the complete destruction of all joints (ankylosis, a, arrows) and shortening of phalanges in the loCII-D1CC mouse and normal joints in loCII-DBA/1 mice.
