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Western blot analysis of protein expression of K-Ras, Cox-2, Akt1/2, and pAkt in H460 human NSCLC xenografts after treatment with MZ-J-7-138 given s.c. at a dose of 10 μg/day, docetaxel given i.p. at a concentration of 25 mg/kg BW at day 1 and 6, or its combination. Three representative tumors from each group are shown, and the experiments were repeated at least three times.
