Table 1.
Effect of therapy with GHRH antagonists MZ-J-7-138 and JV-1-92 on the lung weight (lung block) and body weight of nude mice xenografted orthotopically with H460 human NSCLC
| Groups | Lung block, mg | % Inhibition vs. control | BW (initial), g | BW (final), g |
|---|---|---|---|---|
| Control | 850 ± 57 | 20.60 ± 0.74 | 18.61 ± 0.42 | |
| MZ-J-7-138 (10 μg) | 408 ± 80*** | 52 | 20.50 ± 0.51 | 20.63 ± 0.38*** |
| MZ-J-7-138 (20 μg) | 300 ± 53*** | 65 | 20.44 ± 0.52 | 21.69 ± 0.12*** |
| JV-1-92 (10 μg) | 371 ± 45*** | 56 | 20.62 ± 0.84 | 21.67 ± 0.25*** |
BW, body weight;
***, P < 0.001 vs. control.