Table 2.

Protein levels of K-Ras, Cox-2, Akt1/2, and pAkt in orthotopic xenografts of H460 human NSCLC after treatment with GHRH antagonists MZ-J-7-138 and JV-1-92

	Protein levels (controls accepted as 100%), %
	MZ-J-7-138 (10 μg)	MZ-J-7-138 (20 μg)	JV-1-92 (10 μg)
K-Ras	57 ± 13**	27 ± 8***	22 ± 10***
Cox-2	73 ± 9*	32 ± 2***	42 ± 12***
Akt1/2	83 ± 14	80 ± 12	105 ± 16
pAkt	50 ± 12**	52 ± 11**	32 ± 7***

Values are means ± SE. Protein levels of 5–8 tumors in each group were quantified by densitometric analysis, and the data were normalized to β -actin values.

*, P < 0.05;

**, P < 0.01;

***, P < 0.001 vs. controls.