Table 3.

Effect of therapy with GHRH antagonist MZ-J-7-138, docetaxel, and its combination on the growth of H460 human NSCLC xenografted s.c. into nude mice

Groups	Tumor weight, g (% inhibition)	Tumor volume, mm3 (% inhibition)		Tumor volume doubling time, days
		Initial	Final
Control	1,166 ± 60	85 ± 10	668 ± 53	6.51 ± 0.43
MZ-J-7-138 (10 μg)	823 ± 50*** (30)	83 ± 14	470 ± 25** (30)	11.45 ± 0.42*
Docetaxel2× 25 mg/kg BW	871 ± 65** (25)	87 ± 12	455 ± 35** (32)	12.10 ± 0.35**
MZ-J-7-138 + docetaxel	596 ± 40*** (49)	86 ± 11	298 ± 40*** (65)	15.49 ± 2.1***

Values show the mean ± SE.

*, P < 0.05;

**, P < 0.01;

***, P < 0.001 vs. control (one-way ANOVA test).