Table 4.

Effect of treatment with GHRH antagonists MZ-J-7-138, docetaxel, and its combination on protein levels of K-Ras, Cox-2, Akt1/2, and pAkt in tumors of H460 human NSCLC xenografted s.c. into nude mice

	Protein levels (Controls accepted as 100%), %
	MZ-J-7-138	Docetaxel	MZ-J-7-138 + docetaxel
K-Ras	27 ± 5***	80 ± 9	28 ± 4***
Cox-2	44 ± 4***	71 ± 6***	40 ± 2***
Akt1/2	99 ± 4	90 ± 8	60 ± 2***
pAkt	42 ± 8***	76 ± 13	51 ± 3***

Values are means ± SE. Protein levels of three tumors in each group were quantified by densitometric analysis, and the data were normalized to β -actin values.

***, P < 0.001 vs. controls.