Table 1.
Tumors | Nontumoral part of the liver | |||
Solvent (n = 4) | Halofuginone (n = 5) | Solvent (n = 4) | Halofuginone (n = 5) | |
MMP-9 | 1437 ± 160 | 534 ± 381* | 1249 ± 267 | 134 ± 47* |
Total MMP-2 | 444 ± 87 | 468 ± 215 | 415 ± 76 | 60 ± 21* |
Active MMP-2 (%) | 38.3 ±2.3 | 15.0 ±12.6* | 28.8 ± 4.5 | 2.8 ± 6.2* |
MMP activity was measured with gelatin zymography in liver samples from animals surviving up to week 24.
Values are in arbitrary units and are presented as mean ± 1 SD.
P = .01, Mann-Whitney test.