Figure 5.

FDG and FPCV MicroPET images and FPCV DWBA images of a mouse with C6, C6-stb-tk+, and C6-stb-sr39tk+ tumors. A nude mouse with three tumors was imaged with a microPET, first with FDG, and, 24 hr later, with FPCV. The mouse was sacrificed immediately after the FPCV scan and used for DWBA. A whole-body single-slice coronal projection image of fluorine-18 activity distribution for FDG is displayed on the left. The second panel shows a single-slice coronal projection image from the FPCV microPET image of the same mouse. The C6-stb-sr39tk+ tumor shows the strongest signal with FPCV. The C6-stb-tk+ tumor shows the next strongest signal, and the control C6 tumor shows minimal signal. The color scale represents the FPCV percent-injected dose per gram of tissue (%ID/g) (0.02% ID/g for the C6 control tumor, 1.9% ID/g for the C6-stb-tk+ tumor, and 5.3% ID/g for the C6-stb-sr39tk+ tumor). The third panel is a photograph of the coronal section used for DWBA (autorad). The fourth panel shows a DWBA obtained directly after the FPCV microPET scan. b, bladder; br, brain.