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. 2000 Feb 25;97(6):2797–2802. doi: 10.1073/pnas.040574897

Figure 1.

Figure 1

Schematic of MLL-AF9 and deletion mutants. All cDNAs were cloned into pUHD10B/X, a modified form of the pUHD10S expression vector (29). MLLΔT contains MLL truncated in the region where translocation breakpoints in MLL commonly occur. MLL3AT encodes the amino-terminal 410 amino acids of MLL and includes all three AT hook motifs of MLL. MLL2AT encodes the amino-terminal 312 amino acids of MLL and contains the two amino-terminal AT hook motifs. All constructs contain an amino-terminal FLAG epitope tag. AT, AT hook motifs; trx, short regions of homology to Trithorax; SNL-1 and SNL-2, subnuclear localization domains 1 and 2 as defined by Yano et al. (33); DMT, DNA methyltransferase homology region.