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Propidium iodide flow cytometric analysis of cell cycle in U937T cell lines expressing MLL-AF9 or MLL3AT
| Cells | % of cells
|
|||
|---|---|---|---|---|
| MLL-AF9
|
MLL3AT
|
|||
| +TET | −TET | +TET | −TET | |
| G0/G1 | 58.18 | 52.31 | 54.78 | 83.20 |
| S | 37.91 | 45.39 | 42.25 | 14.44 |
| G2/M | 3.91 | 2.30 | 2.97 | 2.35 |
| Apoptotic | 0 | 33.43 | 0 | 0 |
Analysis at 24 hr after induction by removal of tetracycline (−TET) reveals induction of apoptosis without cell cycle arrest with MLL-AF9, whereas clones expressing MLL3AT show arrest in G0/G1 without apoptosis.
