Figure 6.
The effect of twice-daily oral dosing with the MEK inhibitor PD184161 on the growth of established Hep3B tumor xenografts in nude mice (n = 7). Nude mice were inoculated in the flank with 3 to 5 million Hep3B cells. Once the tumors had reached 100 mm3, the mice were dosed orally with 300 mg/kg twice daily for 24 days. Tumor measurements were taken every 3 days, and tumor volume is represented in the figure (▲ vehicle; ■ PD184161). There was no statistically significant difference between treatment groups (P = .17).