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PD184161 Has an IC50 of > 10µM against the following Kinases.
| AMPK | GSK3b | PDK1 | S6K1 |
| CDK2/cyclinA | JNK/SAPK1c | Phos. kinase | SAPK2a/p38 |
| CHK1 | Lck | PKA | SAPK2b/p38b2 |
| CK1 | MAPKAP-K1a | PKBph | SAPK3/p38d |
| CK2 | MAPKAP-K2 | PKCa | SAPK4/p38d |
| CKS | MAPK2/ERK2 | PP2a | SGK |
| DYRK1a | MSK1 | ROCK-II |
