Table 2.

Pharmacokinetics of FU in C38 and C26a Tumors.

	CFU (a.u.)	tuptake (min)	t1/2 (min)	Average of All Measured FU Resonance Integrals in Time (a.u.)
C38 control (n = 10)	1603 ± 96.9*	0.94 ± 0.35†	72.99 ± 8.69‡	929.0 ± 55.3§
C38 carbogen (n = 9)	2223 ± 85.5¶	0.71 ± 0.20	65.16 ± 4.63	1223 ± 82.2#
C26a control (n = 7)	581.2 ± 37.6	2.30 ± 0.48	33.17 ± 2.56	192.9 ± 23.6
C26a carbogen (n = 10)	665.3 ± 31.3	0.54 ± 0.22**	33.00 ± 2.12	231.6 ± 31.2

The mean of the maximum concentration of FU (C_FU), the doubling time of FU resonance integral increase in the tumor (t_uptake), the half-life of FU in the tumor (t_1/2), and the average of all resonance integrals (average FU resonance integral) ± SEM are shown for C38 and C26a tumors. Values are calculated from a fit of the mean resonance integral of all mice per group to a biexponential equation (see the Materials and Methods section).

^*P < .0001, compared with the C26a control group.

^†P < .05, compared with the C26a control group.

^‡P < .01, compared with the C26a control group.

^§P < .0001, compared with the C26a control group.

^¶P < .001, compared with the C38 control group.

^#P < .001, compared with the C38 control group.

^**P < .01, compared with the C26a control group.