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The proliferative response of PBMC to SEA and TSST-1 is inhibited by CD38 mAbs. PBMC (4 × 104 cells/well) were cultured with SEA or TSST-1 (1 ng/ml) in the presence of mAbs of the indicated specificity (5 μg/ml). [3H]thymidine incorporation measured at day 4 for PBMC in the absence of blocking mAb was 102.205 ± 11.242 cpm in SEA and 95.802 ± 8.622 cpm in TSST-1.
