Figure 2.

Effects of stress on the DTH response of wild-type (A) and IFNγR−/− (B) mice. Control animals were left undisturbed while stressed animals were restrained for 2.5 h. The right pinnae of all animals were then challenged with DNFB (0.2%). A time course of changes in the thickness of challenged pinnae is shown. Acute stress significantly enhanced the DTH response of wild-type mice (n = 5, *, P < 0.05; **, P < 0.005, independent t test). In contrast, IFNγR−/− mice failed to show a stress-induced enhancement of skin DTH.