Figure 3.

Stress-induced changes in plasma corticosterone levels (A) and blood leukocyte numbers (B–E). Control animals were left undisturbed while stressed animals were restrained for 2.5 h. Wild-type (WT) and IFNγR−/− mice showed a robust stress-induced increase in plasma corticosterone (n = 3, A), and a robust stress-induced decrease in blood lymphocyte (B) and monocyte (C) numbers (n = 5). Wild-type mice also showed a stress-induced increase in blood neutrophil numbers (n = 5, D), which was particularly prominent for CD62L+ neutrophils (E). IFNγR−/− mice failed to show this stress-induced neutrophilia (n = 5). Statistically significant differences are indicated (**, P < 0.005, independent t test).