Table 7.
NRG1 mRNA Expression, ErbB Phosphorylation, and LD50 Values of the CCSST Cell Line Treated with CI-1033 and PD158780.
| Cell Line | qRT-PCR NRG1 | ErbB Phosphorylation | LD50(48 hours) (M) | ||
| Basal | Neuregulin-Induced | CI-1033 | PD158780 | ||
| GG-62 | 100.0 | +++ | +++ | 0.12 | 0.9 |
| DTC1 | 4.47 | + | +++ | 3.5 | > 3.0 |
| KAO | 7.57 | + | +++ | 5.5 | > 3.0 |
| Su-CCS1 | 1.18 | + | +++ | 10.0 | > 3.0 |
| MA-OH1 | 29.41 | + | ++ | 3.5 | > 3.0 |
| MST-1 | 69.55 | ++ | +++ | 0.03 | 0.5 |
ErbB phosphorylation was analyzed by Western blot analysis, and signal intensity was scored as (+) weak, (++) moderate, and (+++) strong.