Table 1.
Summary of In Vivo 1H MRS Data Obtained from RIF-1 Tumors before and 24 Hours after Treatment with Either Saline (n = 6) or 200 mg/kg ZD6126 (n = 6).
| Variable | Saline | ZD6126 | ||
| Pretreatment | Posttreatment | Pretreatment | Posttreatment | |
| Volume (mm3) | 458 ± 65 | 589 ± 85* | 518 ± 52 | 671 ± 57† |
| tCho (mM) | 4.43 ± 0.20 | 5.09 ± 0.17* | 5.73 ± 0.46 | 2.40 ± 0.51* |
| tCr (mM) | 4.81 ± 0.38 | 5.14 ± 0.76 | 4.56 ± 0.73 | 3.14 ± 0.57 |
| Water T2 (milliseconds) | 53.3 ± 1 | 52.8 ± 2 | 51.4 ± 1 | 46.9 ± 4 |
| tCho T2 (milliseconds) | 190 ± 13 | 157 ± 17 | 162 ± 14 | 142 ± 12 |
| tCr T2 (milliseconds) | 142 ± 12 | 133 ± 16 | 138 ± 12 | 116 ± 13 |
| Lactate/water (x10-3) | 3.79 ± 0.80 | 3.08 ± 0.95 | 3.06 ± 0.82 | 1.54 ± 0.68 |
| DDC(x10-6 cm2/sec) | 5.39 ± 0.45 | 5.17 ± 0.48 | 4.72 ± 0.28 | 5.63 ± 1.30 |
| Heterogeneity index (α) | 0.77 ± 0.03 | 0.77 ± 0.01 | 0.75 ± 0.02 | 0.75 ± 0.02 |
Values are mean ± SEM.
*
P < .02, Student's paired t test between pretreatment and posttreatment values.
†
P < .05, Student's paired ttest between pretreatment and posttreatment values.