Table 2.

Tumor Metabolite Concentrations (µmol/kg) Determined by ¹H HRMAS of Unprocessed Tissues and by High-Resolution ¹H MRS of Tissue Extracts of RIF-1 Tumors 24 Hours after Treatment with Saline (n = 6) or 200 mg/kg ZD6126 (n = 6).

Metabolite	HRMAS		Extracts
	Saline	ZD6126	Saline	ZD6126
Choline	1.94 ± 0.3	1.11 ± 0.4	3.23 ± 0.8	2.96 ± 0.8
PC	2.34 ± 0.3	0.65 ± 0.3*	1.03 ± 0.2	0.36 ± 0.03*
GPC	1.80 ± 0.2	0.52 ± 0.1*	1.34 ± 0.2	0.74 ± 0.11†
tCho	6.08 ± 0.8	2.28 ± 0.5*	5.60 ± 0.7	4.07 ± 0.7
PC/GPC	1.32 ± 0.07	1.32 ± 0.42	0.82 ± 0.14	0.58 ± 0.15
Lactate	34.2 ± 11	14.02 ± 2.5	6.24 ± 0.92	7.70 ± 0.73
Alanine	4.34 ± 0.5	2.15 ± 0.46*	2.77 ± 0.3	2.17 ± 0.3
tCr	2.94 ± 0.3	1.55 ± 0.4*	2.94 ± 0.3	1.55 ± 0.4*
Taurine	16 ± 1.8	4.7 ± 1.4*	7.8 ± 0.3	3.07 ± 0.98*
Glycine	3.48 ± 0.31	2.53 ± 0.7	2.35 ± 0.18	1.51 ± 0.41
Acetate	0.73 ± 0.09	0.55 ± 0.15	0.94 ± 0.17	1.21 ± 0.10

Values are mean ± SEM.

^*P < .02, Student's t test.

^†P < .05, Student's t test.