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Summary of E3 Ubiquitin Ligases for p53 and c-Myc.
| Ubiquitin Ligase | Type | Subunits | Cell Growth | Cancer Status | |
| p53 (yin) | MDM2 | RING | 1 | + | Oncogene |
| PirH2 | RING | 1 | ? | ? | |
| COP1 | RING | 1 | ? | ? | |
| CHIP | U-box | 1 | ? | ? | |
| E6AP | HECT | 2 | ? | ? | |
| ARF-BP1/HectH9 | HECT | 1 | + | ? | |
| Cullin 7 | Cul | 2–4? | ? | ? | |
| Cul5-Roc1- | Cul | 4 | ? | ? | |
| E1B55K | |||||
| c-Myc (yang) | Skp2 | RING | 4 | + | Oncogene |
| Fbw7 | RING | 4 | - | Tumor suppressor | |
| ARF-BP1/HectH9 | HECT | 1 | + | Oncogene? |
(+) Promotes cell growth; (-) suppresses cell growth; (?) unsure or untested.
