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. 2000 Mar 7;97(6):2858–2863. doi: 10.1073/pnas.050587897

Figure 4.

Figure 4

Effects of integrin antagonists on Fn binding by epithelial cells (A), M1 protein (B), and M1+ bacteria (C). (A) Effect of SJ755 and anti-integrin α5β1 mAb on binding of A549 (hatched bars) and HTE (open bars) cells to a 120-kDa α-chymotryptic Fn fragment. (B) Effects of SJ755, soluble M1, and anti-Fn Ab on binding of Fn to immobilized M1 protein. (C) Effect of SJ755 on Fn binding to immobilized M1+ bacteria. Percent inhibition of Fn binding was calculated as [absorbance (Abs) of control wells (lacking an inhibitor) − Abs of wells containing inhibitor]/(Abs of control wells) × 100. Data in A are the means from experiments performed in triplicate. Data in B and C are the means ± SEM from three independent experiments (n = 9).