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. Author manuscript; available in PMC: 2006 Oct 13.
Published in final edited form as: Arthritis Rheum. 1998 Aug;41(8):1398–1406. doi: 10.1002/1529-0131(199808)41:8<1398::AID-ART8>3.0.CO;2-B

Figure 5.

Figure 5

Interleukin-4 (IL4) inhibition of IL-1-induced matrix metalloproteinase mRNA is dose dependent. Total RNA was isolated from human synovial fibroblast cultures 6 hours after addition of 100 ng of IL-1β/ml alone or in the presence of the indicated doses of IL-4. Shown are data from 3 independent experiments. The IC50(50% inhibition concentration) calculated from these data is ~0.3 ng of IL-4/ml.