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. Author manuscript; available in PMC: 2006 Oct 13.
Published in final edited form as: Arthritis Rheum. 1998 Aug;41(8):1398–1406. doi: 10.1002/1529-0131(199808)41:8<1398::AID-ART8>3.0.CO;2-B

Figure 8.

Figure 8

Interleukin-4 (IL-4) inhibition of IL-1-induced expression of matrix metalloproteinase is independent of prostaglandin E2 (PGE2). Indicated amounts (ng/ml) or PGE2 (PGE) were added to cultures of human synovial fibroblasts simultaneously with 100 ng of IL-1β/ml and 10 ng of IL-4/ml. Total RNA was isolated after 6 hours, and Northern blots were hybridized with cDNA probes corresponding to collagenase, stromelysin, and GAPDH. The blot was quantitated and normalized to GAPDH as described abovc. Shown are data from 3 independent experiments for collagenase and 2 for stromelysin.