TABLE 2.

Summary of phenotypes analyzed, number of animals, and mean age (in days) at which the animals were analyzed

Phenotype	Description	No. of animals	Mean age (days)
Weight, 6 wk	Body weight at the beginning of testing.	2516	42
Immunology	CD4, CD3, CD8, and B220 antibody staining.	1872	42
OFT	Open field arena: distance in the perimeter, the center, and total distance in 5 min.	2504	45
EPM	Elevated plus maze: distance traveled, time spent, and entries into closed and open arms.	2452	46
FN	Food hyponeophagia: time taken to sample a novel foodstuff (overnight food deprivation).	2474	47
Burrowing	No. of pellets removed from burrow in 1.5 hr.	2455	48
Activity	Activity measured in a home cage in 30 min.	2445	48
Startle	Startle to a loud noise.	1948	52
Context freezing	Freezing to the context in which a tone is associated with a foot shock.	2070	55
Cue freezing	Freezing to a tone after association with a foot shock.	2110	56
Plethysmography	Animals sensitized by injection with ovalbumin inhale metacholine and changes in lung function are measured by plethysmography (a model of asthma). Respiratory rate, tidal volume, minute volume, expiratory time, inspiratory time, and enhanced pause are recorded with and without exposure to metacholine.	2304	63
IPGTT	Glucose and insulin values taken at 0, 15, 30, and 75 min after i.p. glucose injection (a model of type 2 diabetes mellitus).	2334	68
Weight, 10 wk	Body weight at the end of testing.	2319	70
FBC	Full blood count (hematocrit, Hb concentration, mean cellular volume, mean cellular Hb concentration, white cell count, platelet count).	1892	71
Tissue harvest	Adrenal weight.	2309	71
Wound healing	Reduction in size of a 2-mm ear punch hole.	2273	71
Biochemistry	Albumin, alkaline phosphatase, alanine transaminase, aspartate transaminase, calcium, chloride, creatinine, high-density lipoprotein, low-density lipoprotein, phosphorous, sodium, total cholesterol, total protein, triglycerides.	1890	71