Figure 2.—

A range of mosaic-eye phenotypes is associated with gin mutations. The strength of the mosaic-eye phenotype can vary from unilateral mosaics, here with three cells that have lost the wild-type golden allele (A), to eyes that are almost all golden with only a few wild-type cells present (B). Mosaicism can also occur bilaterally, where each patch of golden cells may indicate an independent somatic mutation event (C). Mosaic eyes were also found in gin-2/gin-2; gol/+; albino/+ (D) and gin-5/gin-5; gol/+; pig-5/+ (E) embryos. Loss-of-function mosaic patches were determined to be in albino and pig-5, respectively, because the light patches did not darken to golden brown on day 4. The shadows in the top right of A and the bottom left of B are caused by the contralateral eye.