Figure 2.—

Radiation hypersensitivity of checkpoint mutants. (A) Dose-response analysis of radiation hypersensitivity. Comparisons of IR hypersensitivity of clk-2 mutant strains that were independently outcrossed (a and b) at doses of (B) 80 Gy and (C) 60 Gy. (D) Apoptosis removes germ cells with lethal levels of DNA damage. For all panels, progeny derived from irradiated L4 larvae were scored for embryonic lethality (n = 5 broods scored/strain). Percentage of survival was normalized relative to unirradiated controls and standard deviations are shown.