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. 2004 Jan;164(1):133–141. doi: 10.1016/S0002-9440(10)63104-5

Figure 3.

Figure 3

Effect of renal ischemia on renal function in WT, C3-deficient, and complement-inhibited mice. a: WT and C3-deficient mice underwent 55 minutes of bilateral renal ischemia 4 hours after receiving anti-P-selectin mAb or isotype-matched control mAb, as indicated. Blood urea nitrogen was measured 24 to 48 hours after removal of the clamps. b: WT mice were complement-inhibited by intraperitoneal administration of anti-C5 mAb 16 hours before induction of ischemia. WT and anti-C5-treated WT mice underwent 55 minutes of bilateral renal ischemia 4 hours after receiving anti-P-selectin mAb as indicated. Reperfusion was for 24 hours. Dashed line represents BUN measurement in normal animals. Numbers in parentheses represent the number of animals studied in each group. P values are for comparisons as shown. P values of <0.05 were seen after 48 hours of reperfusion.