Figure 1.

DNA adduct profiles in apoE-knockout mice after 12 weeks of chronic B[a]P exposure. Top row: Chromatograms of aorta, lung, and liver (a, b, and c, respectively) of control animals. Bottom row: Results of aorta, lung, and liver (e, f, and g, respectively) of B[a]P-exposed animals. d and h: MQ sample and a BPDE-DNA adduct standard (1 adduct per 10⁷ nucleotides), respectively. Differences in chromatography are because of interassay variations. In the B[a]P-treated mice a clear DNA adduct spot was found that migrated at the same position as the BPDE-DNA adduct standard (as indicated by the circles). Additional spots were not used for quantification purposes.