Table 2.
Expression of 51 of the 52 Markers Analyzed in the Entire DLBCL Series, Indicating Number of Positive/Total Analyzed Cases
| Protein | Positive cases | Percentage |
|---|---|---|
| Apoptosis | ||
| MBcl-2 | 122/224 | 54.46 |
| Bax | 194/215 | 90.23 |
| Bcl-XL | 73/188 | 38.83 |
| Mcl1 | 107/186 | 57.53 |
| Survivin | 70/217 | 32.26 |
| p65/RelA | 116/225 | 51.56 |
| Caspase 3 active | 17/194 | 8.77 |
| Bcl-10 | 75/188 | 39.89 |
| CD95 | 69/169 | 40.83 |
| TUNEL | 141/191 | 73.82 |
| Transcription factors | ||
| Oct-1 | 186/187 | 99.46 |
| Oct-2 | 189/192 | 98.44 |
| Bob-1 | 176/180 | 97.78 |
| PU1 | 11/194 | 5.67 |
| Pax-5 | 209/215 | 97.21 |
| MUM-1 | 113/206 | 54.85 |
| STAT3 | 23/224 | 10.27 |
| B-cell differentiation | ||
| Bcl-6 | 168/207 | 81.16 |
| CD38 | 73/204 | 35.78 |
| CD138 | 15/219 | 6.85 |
| CD5 | 53/188 | 28.19 |
| CD10 | 51/182 | 28.02 |
| CD20 | 224/231 | 96.97 |
| CD30 | 41/206 | 19.90 |
| EMA | 8/214 | 3.74 |
| CD27 | 30/209 | 14.35 |
| Cell cycle | ||
| Cyclin A | 107/202 | 52.97 |
| Cyclin B1 | 37/221 | 16.74 |
| Cyclin D1 | 0/235 | 0 |
| Cyclin D3 | 50/229 | 21.83 |
| Cyclin E | 25/214 | 11.68 |
| CDK1 | 40/179 | 22.35 |
| CDK2 | 151/198 | 76.26 |
| CDK6 | 111/174 | 63.79 |
| P21 | 20/226 | 8.85 |
| P16 | 166/212 | 78.30 |
| P27 | 78/216 | 36.11 |
| MIB1 | 131/210 | 63.38 |
| SKP2 | 26/214 | 12.15 |
| P53 | 37/222 | 16.66 |
| Hdm2 | 120/221 | 54.30 |
| Rb | 112/215 | 52.09 |
| Rb-P | 57/189 | 30.16 |
| Other | ||
| PTEN | 211/211 | 100 |
| DP-1 | 114/155 | 73.55 |
| PKCβ | 55/186 | 29.57 |
| TOPO | 186/207 | 89.85 |
| GST | 150/209 | 71.77 |
| c-kit | 60/213 | 28.17 |
| ALK | 1/213 | 0.47 |
| EBER | 20/221 | 9.05 |
CD3 was negative in all cases.