Table 3.
Changes in Macrovasculature in Male and Female Remnant Kidney Rats at 12 Weeks
| Male
|
Female
|
|||
|---|---|---|---|---|
| Sham (n = 6) | RK (n = 8) | Sham (n = 6) | RK (n = 8) | |
| Interlobular artery | ||||
| Number of SMC (/cross-section) | 6.2 ± 1.0 | 11.2 ± 4.2 | 6.8 ± 1.1 | 8.6 ± 5.1* |
| SMC proliferation (/each vessel) | 0.17 ± 0.03 | 0.38 ± 0.04 | 0.15 ± 0.02 | 0.18 ± 0.02* |
| Number of EC (/cross-section) | 6.1 ± 0.8 | 7.0 ± 0.7 | 6.3 ± 0.4 | 6.4 ± 2.9 |
| EC proliferation (/each vessel) | 0.12 ± 0.04 | 0.20 ± 0.03 | 0.11 ± 0.01 | 0.12 ± 0.02 |
| Wall area (μm2) | 659.3 ± 203.2 | 1190.4 ± 237.2 | 620.4 ± 253.0 | 875.7 ± 334.6* |
| Arcuate artery | ||||
| Number of SMC (/cross-section) | 17.8 ± 1.7 | 29.5 ± 6.7 | 15.2 ± 1.4 | 20.5 ± 6.0* |
| SMC proliferation (/each vessel) | 0.20 ± 0.10 | 0.35 ± 0.06 | 0.13 ± 0.02 | 0.22 ± 0.08* |
| Number of EC (/cross-section) | 9.0 ± 1.0 | 14.5 ± 2.4 | 10.4 ± 1.6 | 15.5 ± 2.6 |
| EC proliferation (/each vessel) | 0.32 ± 0.11 | 0.40 ± 0.12 | 0.11 ± 0.01 | 0.28 ± 0.09 |
| Wall area (μm2) | 2876.2 ± 840.5 | 5737.6 ± 3206.9 | 2180.2 ± 1001.3 | 3690.1 ± 1440.3* |
Data is expressed as mean ± SD.
Abbreviations: SMC, smooth muscle cell, EC, endothelial cell.
*
P <0.05 vs. male RK.